Study of Solvent Effect on Alkali catalysed Hydrolysis of Methyl nicotinate in Water-Dioxane Medium

Abstract

At temperatures ranging from 250 to 450 degrees Celsius, the alkalicatalyzed hydrolysis of methylnicotinate was examined in Dioxane-water combinations of varied compositions, commencing from 10% to 50% Dioxane (v/v). The rate lowers as the Dioxane content increases (aprotic solvent). The Arrhenius equation was used to calculate the isocomposition activation energy (Ec). Wynne-Jones and Eyring equations were used to compute activation enthalpy, entropy, and free energy. Researchers have discovered that the solvation mechanism can be deduced from the patterns of variation in these numbers. Additional considerations included water molecules' involvement in the transition state as well as changes in molar polarization energy